Why the study?
Does metoprolol improve symptoms in patients with intermittent explosive disorder refractory to previous medications?
Does metoprolol improve symptoms in patients with intermittent explosive disorder refractory to previous medications?
Metoprolol may provide dramatic clinical improvement in patients with intermittent explosive disorder who are refractory to other medications.
May support metoprolol trial in refractory intermittent explosive disorder; hypothesis-generating and requires randomized confirmation.
Metoprolol, a selective beta 1-adrenoreceptor blocker, was administered to two patients with intermittent explosive disorder who had not done well with previous medications, including propranolol and carbamazepine. Both patients improved dramatically, suggesting clinical and theoretical relevance.
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Jeffrey A. Mattes (1985) studied this question.
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