Studies of cardioselectivity and partial agonist activity in beta‐ adrenoceptor blockade comparing effects on heart rate and peak expiratory flow rate during exercise.

Healthy volunteers

Single doses of beta-adrenoceptor antagonists: propranolol (80 mg oral or 0.2 mg/kg IV), metoprolol (100 mg oral or 0.2 mg/kg IV), oxprenolol (80 mg oral or 0.2 mg/kg IV), practolol (200 mg oral or 1 mg/kg IV), or pindolol (0.05 mg/kg IV)

Heart rate and peak expiratory flow rate (PEFR) at rest and during standardized exercisesurrogate