Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 19, 2018Frontiers in ImmunologyOpen Access

Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The role of the transcription factor STAT3 in hypertension-induced cardiac hypertrophy and its broader crosstalk with inflammation in heart function and disease remained unsettled.

Design

Review

Authors

MKMazen KurdiLebanese UniversityCZCarlos ZgheibBanner - University Medical Center TucsonGBGeorge W. BoozHeart Failure & Transplant

Discussion

Loading...

Member takes

Implication

Cardiomyocyte-specific STAT3 deletion does not drive hypertension-induced hypertrophy; challenges global knockout data and leaves open cell-specific roles.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Kurdi et al. (2018) studied this question.

synapsesocial.com/papers/6a70970aa7fbea1e44082070https://doi.org/10.3389/fimmu.2018.03029

Topics

Myocarditis
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy2000 · 275 citations
  2. 2Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury2004 · 387 citations
  3. 3Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction2016 · 253 citations
  4. 4STAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose2013 · 66 citations
  5. 5Chronic treatment of mice with leukemia inhibitory factor does not cause adverse cardiac remodeling but improves heart function2012 · 21 citations