Population
Hepatocytes isolated from three species: human, rat, and mouse
Comparison
Stimulation with tumor necrosis factor alpha… vs Comparison between species and unstimulated…
Design
Preclinical
Authors
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Species differences in hepatocyte NO production limit rodent model translation; leaves open human-specific iNOS validation in liver research.
There are significant species-specific differences in the regulation, expression, and cofactor requirements of inducible nitric oxide synthase in human, rat, and mouse hepatocytes.
Nüssler et al. (1995) studied this question.
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