What question did this study set out to answer?

To evaluate the impact of subchronic oral exposure to various sizes and doses of silver nanoparticles and silver acetate on gut microbiota composition and ileal mucosal gene expression.

May 30, 2014Nanotoxicology

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

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Authors

KWKatherine M. WilliamsNational Board of Health and Welfare JMJessica Milner MBMary D. BoudreauNational Center for Toxicological Research

Discussion

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Implication

Animal study demonstrates that oral silver nanoparticle exposure shifts ileal microbiota and suppresses immune gene expression in rats, indicating compromised intestinal homeostasis.

Key Points

To evaluate the impact of subchronic oral exposure to various sizes and doses of silver nanoparticles and silver acetate on gut microbiota composition and ileal mucosal gene expression.
Male and female Sprague-Dawley rats received twice-daily oral gavages for 13 weeks with silver nanoparticles (10, 75, or 110 nm at 9, 18, or 36 mg/kg/day) or silver acetate (100, 200, or 400 mg/kg/day).
DNA-based analyses and host gene expression profiling were performed on ileal mucosal tissues to evaluate microbial shifts and immunomodulatory gene activity.
Exposure provoked size- and dose-dependent shifts toward Gram-negative bacteria, with 10 nm particles and low-dose silver acetate causing marked reductions in the Firmicutes phylum and Lactobacillus genus.
Smaller nanoparticle sizes and lower doses significantly suppressed the expression of key immunomodulatory genes, including MUC3, TLR2, TLR4, GPR43, and FOXP3, with prominent gender-specific immune alterations.

Cite This Study

Williams et al. (2014) studied this question.

synapsesocial.com/papers/6a70977de5469ee92be14bad https://doi.org/10.3109/17435390.2014.921346

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Implication

Animal study demonstrates that oral silver nanoparticle exposure shifts ileal microbiota and suppresses immune gene expression in rats, indicating compromised intestinal homeostasis.

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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