Subviral particles of rhinovirus type 2 and poliovirus type 2 adsorb to liposomes, providing a potential in vitro model for early steps of viral infection.
Provides in vitro model for picornavirus entry steps; hypothesis-generating, requires cellular validation before broader inference.
Subviral particles ("A particles") were produced from rhinovirus type 2 by treatment with acid and from poliovirus type 2 by incubation at 37 degrees C in a low-ionic-strength buffer. A particles, but not virions, adsorbed to liposomes. It is proposed that these reactions may provide an in vitro model for two early steps of infection.
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Lonberg-Holm et al. (1976) studied this question.
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