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August 1, 1976Journal of VirologyOpen Access

Association of the polioviral RNA polymerase complex with phospholipid membranes

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Population

Polioviral RNA polymerase complex and phospholipid bilayer membranes (liposomes)

Design

Preclinical

Authors

BBByron E. ButterworthCorewell Health Butterworth HospitalESEdward J. ShimshickDuPont (United States)FYF H YinUniversiti of Malaysia Sabah

Discussion

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Implication

Polymerase-membrane association does not enhance activity in vitro; leaves open its functional role in poliovirus replication.

Structured PICO

P
Population
Polioviral RNA polymerase complex and phospholipid bilayer membranes (liposomes)
I
Intervention
Addition of phospholipid bilayer membranes (liposomes) of defined composition
O
Outcome
Association of the RNA polymerase complex with phospholipid membranes and polymerase activitysurrogate

The polioviral RNA polymerase complex associates spontaneously with phospholipid membranes, likely mediated by viral polypeptide X, without enhancing polymerase activity.

Cite This Study

Butterworth et al. (1976) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f5https://doi.org/10.1128/jvi.19.2.457-466.1976
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polyadenylic acid on poliovirus RNA. III. In vitro addition of polyadenylic acid to poliovirus RNAs1975 · 16 citations
  2. 2Evidence for the existence of protomers in the assembly of encephalomyocarditis virus1975 · 41 citations
  3. 3Virus-Specific Proteins Synthesized in Encephalomyocarditis Virus-Infected HeLa Cells1971 · 102 citations
  4. 4The Fluid Mosaic Model of the Structure of Cell Membranes1972 · 9,180 citations
  5. 5The Molecular Organization of Membranes1974 · 1,072 citations