January 1, 1988Nucleic Acids ResearchOpen Access

Measurement of poliovirus RNA polymerase binding to poliovirion and nonviral RNAs using a filter-binding assay

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Population

Purified poliovirus RNA-dependent RNA polymerase and viral/nonviral RNAs

Design

Preclinical

Authors

Discussion

Poliovirus polymerase binding preferences may inform antiviral strategies; leaves open validation in mammalian or human systems.

Population

Purified poliovirus RNA-dependent RNA polymerase and viral/nonviral RNAs

Intervention

Protein-RNA nitrocellulose filter binding assay

Outcome

Binding efficiency and sequence specificity of the polymerase to different RNAssurrogate

Poliovirus RNA polymerase exhibits sequence-specific binding with a preference for G- and/or U-rich sequences.

Oberste et al. (1988) studied this question.

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