Population
Poliovirus RNA-dependent RNA polymerase and single-stranded RNA oligonucleotides
Design
Preclinical
Authors
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May inform antiviral design but should not change practice; leaves open in vivo validation of polymerase binding.
The minimal RNA-binding site size of the poliovirus polymerase is 10 nucleotides, with cooperative binding allowing two polymerase molecules to occupy a 24-nucleotide RNA.
Beckman et al. (1998) studied this question.
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