Population
In vitro model using highly purified preparations of poliovirus RNA-dependent RNA polymerase, 3Dpol, and an…
Comparison
Poliovirus RNA-dependent RNA polymerase 3Dpol… vs Avian myeloblastosis virus reverse transcriptase
Design
Preclinical
Authors
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Poliovirus 3Dpol unwinding may inform antiviral strategies; leaves open extension to other RNA viruses or clinical translation.
Poliovirus RNA-dependent RNA polymerase 3Dpol possesses intrinsic RNA duplex unwinding activity during chain elongation, a property not shared by all polymerases.
Cho et al. (1993) studied this question.
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