July 1, 1975Journal of General Virology

Virus-specific Proteins Associated with the Replication Complex of Poliovirus RNA

View Full Paper

Ask AI

Bookmark

Population

Poliovirus-infected HeLa S3 cells

Design

Preclinical

Authors

ARAllison RoderNational Institutes of Health KKKlaus KoschelThe Wistar Institute

Discussion

Member takes

Implication

Associates poliovirus proteins with RNA synthesis inhibition in animal models; leaves open translation to human antiviral strategies.

Structured PICO

Population

Poliovirus-infected HeLa S3 cells

Intervention

Treatment with cycloheximide, toloylsulphonyl-phenylalanine chloromethyl ketone (TPCK), and iodoacetamide (IAA)

Outcome

RNA-dependent RNA polymerase activity and RNA synthesissurrogate

Large virus precursor proteins are responsible for the inhibition of poliovirus RNA synthesis in vivo and in vitro following treatment with specific inhibitors.

Cite This Study

Roder et al. (1975) studied this question.

synapsesocial.com/papers/6a6fcb4cac440176ef28748e https://doi.org/10.1099/0022-1317-28-1-85

View Full Paper

Ask AI

Bookmark

Virus-specific Proteins Associated with the Replication Complex of Poliovirus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Virus-specific Proteins Associated with the Replication Complex of Poliovirus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider