May 1, 1995Journal of VirologyOpen Access

Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA

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Population

Poliovirus-infected and uninfected tissue culture cells and cell extracts

Comparison

Poliovirus infection and transfection of mutant… vs Uninfected cells and wild-type RNA

Design

Preclinical

Authors

HRHolger RoehlUniversity of California, Irvine BSBert L. SemlerUniversity of California, Irvine

Discussion

Member takes

Implication

Extends poliovirus RNA-host protein mapping; leaves open whether these elements offer antiviral targets pending human validation.

Structured PICO

Population

Poliovirus-infected and uninfected tissue culture cells and cell extracts

Intervention

Poliovirus infection and transfection of mutant full-length positive-sense RNA

Comparator

Uninfected cells and wild-type RNA

Outcome

Protein binding to the 3' end of poliovirus negative-strand RNA and viral replication viability

Identification of 36- and 38-kDa proteins that bind to the 3' end of poliovirus negative-strand RNA, with the 36-kDa protein complex playing an essential role in the viral life cycle.

Cite This Study

Roehl et al. (1995) studied this question.

synapsesocial.com/papers/6a87d301f762332bf8fe8227 https://doi.org/10.1128/jvi.69.5.2954-2961.1995

View Full Paper

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Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider