Key result
Mutations in the 5' noncoding region of poliovirus RNA resulted in deficient viral protein synthesis, suggesting this region acts as a single functional module for translation.
A region of several hundred nucleotides at the 5' end of poliovirus RNA is essential for viral protein synthesis.
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Identifies functional 5' NCR domains for poliovirus viability; leaves open their precise roles in replication.
Trono et al. (1988) studied Poliovirus infection (in vitro). Mutations in the 5' noncoding region of poliovirus type 1 RNA vs. Wild type poliovirus was evaluated on Viral protein synthesis and RNA replication. Mutations in the 5' noncoding region of poliovirus RNA resulted in deficient viral protein synthesis, suggesting this region acts as a single functional module for translation.
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