Key result
Poliovirus RNA harboring a complete 3' noncoding region deletion mutation is infectious, with its replication defect following transfection partly due to nonviral terminal sequences.
An authentic 3' noncoding region is necessary for efficient poliovirus replication, and the observed replication defect in deletion mutants is partly due to nonviral terminal sequences.
No takes yet. Share an insight, caveat, or question.
Authentic 3' NCR required for efficient poliovirus replication; leaves open validation in authentic systems.
Brown et al. (2005) studied Poliovirus infection. 3' noncoding region deletion mutation vs. Parental clone was evaluated on RNA replication and accumulation. Poliovirus RNA harboring a complete 3' noncoding region deletion mutation is infectious, with its replication defect following transfection partly due to nonviral terminal sequences.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: