Population
Two picornavirus RNAs harboring complete deletions of the genomic RNA 3' noncoding regions
Design
Preclinical
Authors
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Challenges template specificity in picornavirus replication; leaves open mechanistic relevance beyond model systems.
Demonstrates that picornaviruses can replicate even with complete deletion of the genomic RNA 3' noncoding region, challenging the necessity of specific 3'-terminal sequences for replication initiation.
Todd et al. (1997) studied this question.
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