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January 1, 2000Cold Spring Harbor Monograph Archive

31 Translation Initiation on Picornavirus RNA

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Key result

Picornavirus RNAs possess long, uncapped 5'-untranslated regions with complex secondary structures, indicating they are translated via a non-conventional mechanism.

Population

Animal picornaviruses and their RNA genomes

Design

Review

Authors

GBGraham J. BelshamStatens Serum InstitutRJRichard J. JacksonUniversity of Liverpool

Discussion

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Implication

May inform antiviral design for picornaviral myocarditis; leaves open validation in cardiac models.

Structured PICO

P
Population
Animal picornaviruses and their RNA genomes

Highlights the unique structural features of picornavirus RNA that require non-canonical translation initiation.

Cite This Study

Belsham et al. (2000) conducted a review in Picornavirus. Picornavirus RNAs possess long, uncapped 5'-untranslated regions with complex secondary structures, indicating they are translated via a non-conventional mechanism.

synapsesocial.com/papers/6a96b014c00de92d9bfbca02https://doi.org/10.1101/087969618.39.869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Dicistronic Nature of Picornavirus Genomes? Diverse Translation Mechanisms Enable the Expression of Accessory Proteins from Alternate Open Reading Frames2026 · 1 citations
  2. 2Introducing Recombinant Picornaviral Genomes into Cells2011
  3. 319 Initiation of Translation by Picornavirus RNAs1996 · 66 citations
  4. 4New insights into internal ribosome entry site elements relevant for viral gene expression2008 · 129 citations
  5. 5RNA-protein interactions in regulation of picornavirus RNA translation1996 · 251 citations