RNA-protein interactions in regulation of picornavirus RNA translation
Key result
Cellular proteins, including La and polypyrimidine tract-binding protein, functionally interact with picornavirus internal ribosome entry site (IRES) elements to regulate viral RNA translation.
Population
in vitro translation systems and picornavirus RNA
Design
Review
Authors
Discussion
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Member takes
Implication
May guide antiviral target discovery; leaves open clinical relevance in picornaviral disease.
Structured PICO
P
Population
in vitro translation systems (rabbit reticulocyte lysate) and picornavirus RNA (cardiovirus, aphthovirus, enterovirus, rhinovirus)
E
Exposure
Supplementation with additional cellular proteins (e.g., La, polypyrimidine tract-binding protein)
O
Outcome
Translation efficiency and production of aberrant initiation products
Cellular proteins such as La and polypyrimidine tract-binding protein play a functional role in interacting with picornavirus IRES elements to regulate RNA translation.
Limitations
- The function and significance of many observed RNA-protein interactions are not always known.
Cite This Study
Belsham et al. (1996) conducted a review in Picornavirus infection. Cellular proteins (La and polypyrimidine tract-binding protein) was evaluated. Cellular proteins, including La and polypyrimidine tract-binding protein, functionally interact with picornavirus internal ribosome entry site (IRES) elements to regulate viral RNA translation.