November 1, 1995Journal of VirologyOpen Access

Cell proteins bind to a linear polypyrimidine-rich sequence within the 5'-untranslated region of rhinovirus 14 RNA

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Population

Human rhinovirus 14 (HRV-14) RNA and cell proteins

Design

Preclinical

Authors

Discussion

May modulate HRV translation; leaves open functional role in human infection and requires validation before clinical consideration.

Population

Human rhinovirus 14 (HRV-14) RNA and cell proteins

Intervention

Mobility shift, UV cross-linking and Western immunoblot analyses

Outcome

Mapping of specific regions of HRV-14 RNA that bind cell proteins

Identifies specific protein-RNA interactions in the 5'-UTR of rhinovirus 14 that likely play a role in internal initiation of translation.

Rojas-Eisenring et al. (1995) studied this question.

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