Population
In vitro translation system programmed with dicistronic mRNAs containing human rhinovirus-2 or poliovirus…
Comparison
Addition of purified HeLa cell… vs Unsupplemented rabbit reticulocyte lysate or…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open PTB as a cofactor for HRV IRES studies in vivo.
Polypyrimidine-tract binding protein (PTB) is identified as a necessary host cell factor for efficient internal ribosome entry site (IRES)-dependent translation of human rhinovirus-2 RNA, acting synergistically with another unidentified factor.
Hunt et al. (1999) studied this question.
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