Key result
A specific translation initiation stimulatory activity for human rhinovirus RNA found in HeLa cells is proposed to be due to a high molecular weight complex containing a 97K polypeptide and PTB.
Population
In vitro translation systems and viral RNAs
Comparison
Addition of HeLa cell factors vs Rabbit reticulocyte lysates without HeLa cell…
Design
Preclinical
Authors
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HeLa factors enable HRV IRES translation unlike EMCV; leaves open the specific cofactor's identity and in vivo role.
The specific translation initiation stimulatory activity for human rhinovirus RNA in HeLa cells is proposed to be driven by a high molecular weight complex containing a 97K polypeptide and polypyrimidine tract binding protein (PTB).
Borman et al. (1993) studied Human rhinovirus RNA translation. HeLa cell extracts vs. Rabbit reticulocyte lysates alone was evaluated on Translation initiation efficiency and protein cross-linking. A specific translation initiation stimulatory activity for human rhinovirus RNA found in HeLa cells is proposed to be due to a high molecular weight complex containing a 97K polypeptide and PTB.
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