Population
HeLa cell extract, rabbit reticulocyte lysates, and poliovirus 5' noncoding region (5'NCR)
Comparison
Translation competition assays and UV… vs Presence vs absence of HeLa cell extract
Design
Preclinical
Authors
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May identify poliovirus translation targets; leaves open validation in human models before therapeutic consideration.
The study identifies specific functional domains in the poliovirus 5' noncoding region and the HeLa cell proteins that interact with them to initiate translation.
Gebhard et al. (1992) studied this question.
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