Population
In vitro translation system using poliovirus RNA and HeLa cell ribosomal salt wash fraction
Comparison
Mutation of a conserved oligopyrimidine tract… vs Wild-type RNA / no competition
Design
Preclinical
Authors
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May inform picornavirus antiviral design; leaves open in vivo validation and therapeutic translation.
Identified a cis-acting oligopyrimidine element essential for poliovirus translation and a 57-kDa cellular protein likely involved in the process.
Pestova et al. (1991) studied this question.
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