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August 1, 1992Journal of VirologyOpen Access

Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA

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Population

Poliovirus RNA (internal ribosome entry site within the 5' noncoding region)

Design

Preclinical

Authors

AHAurelia A. HallerCenters for Disease Control and PreventionBSBert L. SemlerUniversity of California, Irvine

Discussion

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Implication

Cautions against clinical translation from animal models; leaves open extension to human viral or RNA-based therapies.

Structured PICO

P
Population
Poliovirus RNA (internal ribosome entry site within the 5' noncoding region)
I
Intervention
Linker scanning mutagenesis
O
Outcome
Translation initiation and RNA-protein interactionssurrogate

Demonstrates that specific stem-loop structures and RNA-protein interactions in the 5' noncoding region of poliovirus RNA are critical for cap-independent translation initiation.

Cite This Study

Haller et al. (1992) studied this question.

synapsesocial.com/papers/6a7055ae53da1ffdb507a2d9https://doi.org/10.1128/jvi.66.8.5075-5086.1992
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region1991 · 97 citations
  2. 2An internal 5'-noncoding region required for translation of poliovirus RNA in vitro1988 · 80 citations
  3. 3Conservation of RNA-protein interactions among picornaviruses1992 · 59 citations
  4. 4Genetic variation occurring on the genome of an in vitro insertion mutant of poliovirus type 11989 · 56 citations
  5. 5A region of the 5' noncoding region of foot-and-mouth disease virus RNA directs efficient internal initiation of protein synthesis within cells: involvement with the role of L protease in translational control1990 · 183 citations