November 1, 1989BioEssays
Poliovirus translation: A paradigm for a novel initiation mechanism
Population
Poliovirus RNA and eukaryotic cellular mRNAs
Design
Review
Authors
Discussion
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Member takes
Implication
May inform antiviral strategies against poliovirus; leaves open extension to other RNA viruses or clinical translation.
Structured PICO
P
Population
Poliovirus RNA and eukaryotic cellular mRNAs
Poliovirus utilizes a cap-independent translation mechanism via internal ribosome binding, which is crucial for host protein synthesis shut-off and viral neurovirulence.
Cite This Study
Sonenberg et al. (1989) studied this question.