Key result
Internal ribosome binding to the 5'-untranslated region mediates the translation of poliovirus mRNA, a mechanism that may also be utilized by other viral and cellular mRNAs.
Population
Poliovirus mRNA and eukaryotic translation mechanisms
Design
Review
Authors
Discussion
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Member takes
Implication
Offers potential antiviral targets via IRES inhibition; leaves open broader roles in cellular mRNAs.
Structured PICO
P
Population
Poliovirus mRNA and eukaryotic translation mechanisms
The paper reviews the mechanism of internal ribosome entry site (IRES)-mediated translation initiation in poliovirus.
Cite This Study
Sonenberg et al. (2017) reported a review. Internal ribosome binding to the 5'-untranslated region mediates the translation of poliovirus mRNA, a mechanism that may also be utilized by other viral and cellular mRNAs.