Population
HeLa cells, neuronal cells, and reticulocyte lysates infected with wild-type or mutant poliovirus
Comparison
Mutant poliovirus containing two gross deletions… vs Wild-type poliovirus
Design
Preclinical
Authors
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Minimal IRES supports poliovirus infectivity despite growth defects; leaves open in vivo attenuation potential.
A minimum internal ribosome entry site (IRES) in poliovirus is sufficient for infectivity but results in delayed protein synthesis and slow viral growth.
Haller et al. (1993) studied this question.
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