Population
Cells in culture transfected with modified cDNAs encoding the 5' noncoding region of the poliovirus genome
Comparison
Cotransfection with a complete infectious… vs Assayed alone
Design
Preclinical
Authors
Loading...
Indicates infection remodels translation to relax IRES needs; leaves open whether this extends to antiviral targeting in humans.
Virus infection modifies the cellular translational machinery, allowing shortened forms of the 5' NCR to be sufficient for cap-independent translation.
Percy et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: