Key result
A mutation in domain IV of the poliovirus RNA 5' noncoding region reduced binding of host cell proteins (approximately 39-42 kDa) and reduced translation both in vitro and in vivo.
Population
Uninfected HeLa cell extracts and neuroblastoma extracts
Comparison
Mutation in domain IV of the 5' noncoding region… vs Wild-type domain IV
Design
Preclinical
Authors
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Cellular protein binding to poliovirus IRES may modulate translation; leaves open factor identification and antiviral relevance.
Host cell proteins of approximately 39, 40, and 42 kDa interact with domain IV of the poliovirus RNA 5' noncoding region, playing a role in viral translation.
Blyn et al. (1995) studied Poliovirus infection. Mutation in domain IV of the 5' noncoding region vs. Wild-type domain IV was evaluated on Protein binding and translational efficiency. A mutation in domain IV of the poliovirus RNA 5' noncoding region reduced binding of host cell proteins (approximately 39-42 kDa) and reduced translation both in vitro and in vivo.
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