Population
In vitro translation models of encephalomyocarditis virus (EMCV) RNAs
Comparison
Alteration of the reporter cistron and the size… vs Wild-type bulge vs enlarged bulge; viral…
Design
Preclinical
Authors
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PTB maintains IRES structure when needed rather than serving as essential factor; extends mechanistic models but leaves open in vivo validation for therapeutic targeting.
PTB is not an essential and universal internal initiation factor for cardiovirus RNAs, but rather helps maintain appropriate higher-order structure when required.
Kaminski et al. (1998) studied this question.
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