Key result
The 57-kDa cytoplasmic RNA-binding protein required for picornavirus RNA translation is identical to the nuclear pyrimidine tract-binding protein, and its immunodepletion inhibits viral translation.
Population
HeLa cell-free lysate, poliovirus and encephalomyocarditis virus mRNAs, recombinant PTB
Comparison
Immunodepletion of p57/PTB; binding assays with… vs Mutated derivative of hairpin, unrelated RNAs…
Design
Preclinical
Authors
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May inform IRES-targeted antivirals; leaves open validation in infection models.
The 57-kDa cytoplasmic RNA-binding protein required for picornavirus RNA translation is identical to the nuclear pyrimidine tract-binding protein (PTB).
Hellen et al. (1993) studied this question. Immunodepletion of p57/PTB was evaluated on Translation of poliovirus and encephalomyocarditis virus mRNAs. The 57-kDa cytoplasmic RNA-binding protein required for picornavirus RNA translation is identical to the nuclear pyrimidine tract-binding protein, and its immunodepletion inhibits viral translation.
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