Key result
Depletion of PCBP2 in HeLa cell extracts significantly diminished translation of type I picornavirus IRES elements, but not type II elements, demonstrating its essential role in type I initiation.
PCBP2 is essential for internal initiation of translation on picornavirus type I IRES elements but dispensable for structurally distinct type II elements.
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May inform selective antiviral design for type I picornaviruses; leaves open translation to in vivo cardiac models.
Walter et al. (1999) studied Picornavirus translation. PCBP2 depletion and reconstitution was evaluated on Translation of reporter RNAs containing type I and type II picornavirus IRES elements. Depletion of PCBP2 in HeLa cell extracts significantly diminished translation of type I picornavirus IRES elements, but not type II elements, demonstrating its essential role in type I initiation.
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