Population
Dicistronic mRNAs containing reporter genes and picornavirus internal ribosome entry site (IRES) elements
Comparison
Placement of picornavirus IRES elements… vs Monocistronic mRNAs or mRNAs with hepatitis C…
Design
Preclinical
Authors
Loading...
Preclinical data with no immediate clinical implications; leaves open whether picornavirus IRES mechanisms extend to mammalian systems or applications.
Picornavirus IRES elements can stimulate translation of upstream genes in cis by capturing eIF4F and providing it to the 5'-end of the RNA.
Jünemann et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: