Key result
Multimerization of the cellular protein PCBP2, localized to its second KH domain, is required for efficient RNA binding and cap-independent translation of poliovirus RNA.
Multimerization of the cellular protein PCBP2 is essential for efficient RNA binding and cap-independent translation of poliovirus RNA.
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May guide host-directed antivirals against poliovirus; leaves open human applicability.
Bedard et al. (2004) studied Picornavirus cap-independent translation. PCBP2 multimerization was evaluated on RNA binding and cap-independent translation of poliovirus RNA. Multimerization of the cellular protein PCBP2, localized to its second KH domain, is required for efficient RNA binding and cap-independent translation of poliovirus RNA.
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