Key result
Cleavage of PCBP2 by poliovirus proteinases 3C/3CD results in a truncated protein that loses translation function but maintains RNA replication activity, mediating a functional switch.
Cleavage of PCBP2 by poliovirus proteinases mediates the switch from viral translation to RNA replication by removing the KH3 domain.
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Suggests new antiviral targets for enteroviruses; leaves open validation in human systems and clinical relevance.
Perera et al. (2007) studied Poliovirus infection. Viral proteinases 3C/3CD was evaluated on Cleavage of PCBP1 and -2 and its effect on viral translation and RNA replication. Cleavage of PCBP2 by poliovirus proteinases 3C/3CD results in a truncated protein that loses translation function but maintains RNA replication activity, mediating a functional switch.
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