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January 1, 1999Journal of VirologyOpen Access

Cleavage of Poly(A)-Binding Protein by Enterovirus Proteases Concurrent with Inhibition of Translation In Vitro

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Population

In vitro translation assay and HeLa cells

Comparison

Poliovirus infection and enterovirus proteases vs Infections in the presence of guanidine-HCl

Design

Preclinical

Authors

MJMichelle L. JoachimsOklahoma Medical Research FoundationPBPieter C. Van BreugelUtrecht UniversityRLRichard E. LloydUniversity of Minnesota

Discussion

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Implication

May inhibit host translation in coxsackievirus myocarditis; leaves open protease targeting as a research avenue.

Structured PICO

P
Population
In vitro translation assay and HeLa cells
I
Intervention
Poliovirus infection and enterovirus proteases (poliovirus 2A and 3C, coxsackievirus B3 2A)
C
Comparator
Infections in the presence of guanidine-HCl
O
Outcome
Cleavage of poly(A)-binding protein (PABP) and concurrent loss of translational activitysurrogate

Cleavage of PABP by enterovirus proteases may contribute to the inhibition of host translation during infection.

Cite This Study

Joachims et al. (1999) studied this question.

synapsesocial.com/papers/6a70231035aa2c282ce17100https://doi.org/10.1128/jvi.73.1.718-727.1999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus Mutant That Does Not Selectively Inhibit Host Cell Protein Synthesis1985 · 89 citations
  2. 2Translational Control of Poly(A)‐Binding Protein Expression1996 · 52 citations
  3. 3Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA1993 · 88 citations
  4. 4Cap-Dependent and Cap-Independent Translation by Internal Initiation of mRNAs in Cell Extracts Prepared from Saccharomyces cerevisiae1994 · 103 citations
  5. 5The mRNA Poly(A)-Binding Protein: Localization, Abundance, and RNA-Binding Specificity1994 · 250 citations