Population
HeLa cells, purified rabbit PABP, recombinant human PABP, Xenopus oocytes, and recombinant Xenopus PABP
Design
Preclinical
Authors
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May explain translational shutoff in coxsackievirus infection; leaves open relevance to human myocarditis.
The cleavage of PABP by coxsackievirus 2A protease provides a novel mechanism for host protein synthesis shutoff during picornavirus infection.
Kerekatte et al. (1999) studied this question.
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