Population
Poliovirus RNA and PCBP-depleted extracts
Design
Preclinical
Authors
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Highlights PCBP2 domains as antiviral targets; leaves open validation beyond animal models for enteroviral therapies.
Specific domains of PCBP2 have distinct roles in poliovirus translation initiation and RNA replication, and PCBP1 can rescue replication but not translation.
Walter et al. (2002) studied this question.
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