October 1, 1996Proceedings of the National Academy of SciencesOpen Access

Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry.

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Structured PICO

Population

uninfected HeLa cells and Escherichia coli expressing recombinant proteins

Intervention

Isolation and identification of RNA binding protein (PCBP2) and interaction analysis with poliovirus stem-loop IV

Comparator

PCBP1 (related protein) and mutant stem-loop IV RNA

Outcome

Identification of the binding protein and demonstration of specific interaction

Identifies PCBP2 as a specific cellular RNA binding protein that interacts with stem-loop IV of the poliovirus IRES, essential for translation activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

PCBP2 may represent a host antiviral target; leaves open therapeutic relevance pending human validation.

Cite This Study

Blyn et al. (1996) studied this question.

synapsesocial.com/papers/6a201c7e2065d284090df79c https://doi.org/10.1073/pnas.93.20.11115

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Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry.

Structured PICO

Discussion

Implication

Cite This Study

Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider