Key result
Poliovirus subgenomic RNAs lacking capsid-coding sequences replicated in HeLa cells, and truncated transcripts inhibited the replication of full-length poliovirus RNA.
Population
HeLa cells
Comparison
Transfection with poliovirus subgenomic RNAs… vs Full-length poliovirus RNA produced in vitro or…
Design
Preclinical
Authors
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Subgenomic replicons inhibit poliovirus in vitro; leaves open therapeutic translation pending in vivo studies.
Poliovirus subgenomic replicons lacking capsid-coding sequences can replicate in HeLa cells and inhibit the replication of full-length viral RNA in trans.
Kaplan et al. (1988) studied Poliovirus replication. Poliovirus subgenomic replicons vs. Full-length poliovirus RNA was evaluated on Viral RNA replication and inhibition of full-length RNA. Poliovirus subgenomic RNAs lacking capsid-coding sequences replicated in HeLa cells, and truncated transcripts inhibited the replication of full-length poliovirus RNA.
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