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January 1, 1999Journal of VirologyOpen Access

Functional Coupling between Replication and Packaging of Poliovirus Replicon RNA

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Population

Monkey kidney cells constitutively expressing T7 RNA polymerase

Design

Preclinical

Authors

CNConstance I. NugentUniversity of California, RiversideKJKyle L. JohnsonUniversity of California, RiversidePSPeter SarnowStanford University

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Overview

Functional coupling of replication and packaging in poliovirus extends viral assembly models; leaves open human therapeutic translation.

Structured PICO

P
Population
Monkey kidney cells constitutively expressing T7 RNA polymerase
I
Intervention
Inhibition of RNA replication of replicon RNAs using guanidine-resistant helper virus
O
Outcome
Trans-encapsidation of replicon RNA

Demonstrates functional coupling between RNA replication and packaging in poliovirus, suggesting direct interactions between the replication machinery and capsid proteins.

Cite This Study

Nugent et al. (1999) studied this question.

synapsesocial.com/papers/6a71666bf44fa9f079df327dhttps://doi.org/10.1128/jvi.73.1.427-435.1999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Biochemistry of Viruses1963 · 110 citations
  2. 2RNA binding properties of poliovirus subviral particles1995 · 47 citations
  3. 3Construction and characterization of poliovirus subgenomic replicons1988 · 120 citations
  4. 4Complementation of a poliovirus defective genome by a recombinant vaccinia virus which provides poliovirus P1 capsid precursor in trans1993 · 45 citations
  5. 5An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells1991 · 102 citations