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July 1, 1998Journal of General Virology

Encapsidation studies of poliovirus subgenomic replicons.

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Population

Poliovirus subgenomic replicons containing the chloramphenicol acetyltransferase (CAT) gene

Design

Preclinical

Authors

WBWilliam BarclayImperial Valley CollegeNPN PercyMi Corporation (United States)JAJ. W. AlmondInstitut Mérieux (France)

Discussion

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Implication

Indicates poliovirus-specific encapsidation; leaves open broader applicability to other enteroviruses or vector development.

Structured PICO

P
Population
Poliovirus subgenomic replicons containing the chloramphenicol acetyltransferase (CAT) gene
I
Intervention
Trans-encapsidation by helper viruses (Poliovirus types 1, 2, 3, coxsackievirus B4, coxsackievirus A21, rhinovirus 14)
O
Outcome
Efficiency of trans-encapsidation

A specific encapsidation process operates for poliovirus that does not involve RNA sequences within the region of the genome encoding the capsid proteins.

Cite This Study

Barclay et al. (1998) studied this question.

synapsesocial.com/papers/6a845eb0c0e58a00207bf8a2https://doi.org/10.1099/0022-1317-79-7-1725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defective Interfering Particles of Poliovirus I. Isolation and Physical Properties1971 · 153 citations
  2. 2DOUBLE INFECTIONS OF SINGLE CELLS WITH ECHO 7 AND COXSACKIE A9 VIRUSES1959 · 34 citations
  3. 3A poliovirus replicon containing the chloramphenicol acetyltransferase gene can be used to study the replication and encapsidation of poliovirus RNA1992 · 68 citations
  4. 4The 5'-untranslated regions of picornavirus RNAs contain independent functional domains essential for RNA replication and translation1994 · 152 citations
  5. 5In vitro construction of poliovirus defective interfering particles1989 · 88 citations