November 1, 1985Molecular and Cellular Biology
Poliovirus Mutant That Does Not Selectively Inhibit Host Cell Protein Synthesis
Population
HeLa and monkey kidney (CV-1) cells
Comparison
Poliovirus type I mutant with a three base pair… vs Wild-type poliovirus
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
P220 cleavage is required for poliovirus host translation shutoff; extends mechanistic insight but leaves open in vivo and therapeutic relevance.
Structured PICO
P
Population
HeLa and monkey kidney (CV-1) cells
I
Intervention
Poliovirus type I (Mahoney strain) mutant with a three base pair insertion in the P2 segment
C
Comparator
Wild-type poliovirus
O
Outcome
Host cell protein synthesis and viral RNA/protein synthesissurrogate
The study demonstrates that cleavage of P220 is crucial for normal poliovirus-mediated translational inhibition of host cells.
Cite This Study
Bernstein et al. (1985) studied this question.