Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1979Journal of VirologyOpen Access

Poliovirus Polyuridylic Acid Polymerase and RNA Replicase Have the Same Viral Polypeptide

View Full Paper
Ask AI
Bookmark
Share

Population

HeLa cells infected with poliovirus

Design

Preclinical

Authors

JFJames B. FlaneganDBDavid Baltimore

Discussion

Loading...

Member takes

Overview

p63 may represent an antiviral target in poliovirus; leaves open validation in human disease models.

Structured PICO

P
Population
HeLa cells infected with poliovirus
I
Intervention
Isolation and characterization of poly(U) polymerase and RNA replicase
O
Outcome
Identification of the viral polypeptide associated with enzyme activitysurrogate

The study identifies p63 as the key viral polypeptide responsible for poliovirus poly(U) polymerase and RNA replicase activity.

Cite This Study

Flanegan et al. (1979) studied this question.

synapsesocial.com/papers/6a6fcb4cac440176ef287489https://doi.org/10.1128/jvi.29.1.352-360.1979
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation of a Viral Polypeptide Associated with Poliovirus RNA Polymerase1974 · 86 citations
  2. 2Complete translation of poliovirus RNA in a eukaryotic cell-free system.1975 · 90 citations
  3. 3Poliovirus Polypeptides Examined in More Detail1975 · 21 citations
  4. 4Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus.1977 · 348 citations
  5. 5In Vitro Synthesis of Poliovirus Ribonucleic Acid: Role of the Replicative Intermediate1969 · 67 citations