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September 1, 1980Journal of VirologyOpen Access

Identification of poliovirus polypeptide P63 as a soluble RNA-dependent RNA polymerase

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Population

HeLa cells infected with poliovirus

Design

Preclinical

Authors

TDT A Van DykeUniversity of North Carolina at Chapel HillJFJames B. FlaneganUniversity of Florida

Discussion

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Implication

No immediate clinical implications; leaves open p63 as antiviral target pending further validation.

Structured PICO

P
Population
HeLa cells infected with poliovirus
I
Intervention
Isolation and characterization of poliovirus-specific RNA-dependent RNA polymerase (p63)
O
Outcome
Identification and characterization of polymerase activitysurrogate

The study identifies poliovirus polypeptide p63 as an RNA-dependent RNA polymerase capable of copying poliovirion RNA.

Cite This Study

Dyke et al. (1980) studied this question.

synapsesocial.com/papers/6a7c48287eebcb99d4a1613ehttps://doi.org/10.1128/jvi.35.3.732-740.1980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus Polyuridylic Acid Polymerase and RNA Replicase Have the Same Viral Polypeptide1979 · 112 citations
  2. 2Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A).1977 · 180 citations
  3. 3Complete translation of poliovirus RNA in a eukaryotic cell-free system.1975 · 90 citations
  4. 4Poliovirus replicase: a soluble enzyme able to initiate copying of poliovirus RNA.1979 · 94 citations
  5. 5Association of the polioviral RNA polymerase complex with phospholipid membranes1976 · 54 citations