September 1, 1982Journal of VirologyOpen Access

Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitro

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Structured PICO

Population

Rabbits injected with synthetic peptide and HeLa cells infected with poliovirus

Intervention

Antibodies raised against the p63 carboxy-terminal peptide of the poliovirus replicase protein

Outcome

Reaction with virus-specific proteins and inhibition of poliovirus replicase and polyuridylic acid polymerase activities in vitrosurrogate

Antibodies against the p63 carboxy-terminal peptide inhibit poliovirus replicase and polyuridylic acid polymerase activities in vitro, suggesting these activities belong to a single virus-specific polypeptide.

Discussion

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Implication

Antisera inhibition implicates one polypeptide for both activities; hypothesis-generating for poliovirus replication mechanisms.

Cite This Study

Baron et al. (1982) studied this question.

synapsesocial.com/papers/6a7d9188a66bb49753044bb3 https://doi.org/10.1128/jvi.43.3.969-978.1982

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Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitro

Structured PICO

Discussion

Implication

Cite This Study

Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitro

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider