Key result
Poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays on host cytoplasmic membranes, conferring the advantages of surface catalysis to viral RNA replication.
Authors
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Array integrity may enable efficient viral replication; leaves open therapeutic targeting in clinical infections.
Lyle et al. (2002) studied Poliovirus infection. Poliovirus RNA-dependent RNA polymerase was evaluated. Poliovirus RNA-dependent RNA polymerase forms planar and tubular oligomeric arrays on host cytoplasmic membranes, conferring the advantages of surface catalysis to viral RNA replication.
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