Key result
Mutagenesis of a newly identified conserved RNA structure in the 3D(pol)-coding region of the poliovirus genome revealed it is required for viral replication and infectivity.
Identified a novel conserved RNA structure in the poliovirus genome essential for viral replication and infectivity, suggesting a functional interaction with viral protein 3C(pro).
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May guide poliovirus attenuation strategies; leaves open therapeutic translation pending further validation.
Burrill et al. (2013) studied Poliovirus infection. Site-directed mutagenesis of RNA structure in 3D(pol)-coding region vs. Wild-type poliovirus was evaluated on Viral replication and infectivity. Mutagenesis of a newly identified conserved RNA structure in the 3D(pol)-coding region of the poliovirus genome revealed it is required for viral replication and infectivity.
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