January 5, 2010RNAOpen Access

Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays

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Population

Cells infected with mutant positive-strand RNA virus

Comparison

Introduction of catalytically inactive… vs Active polymerases

Design

Preclinical

Authors

JSJeannie F. SpagnoloStanford University EREvan RossignolTE Laboratories (Ireland)EBEsther BullittBoston University

Discussion

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Implication

Animal data suggest multimer interfaces as antiviral targets; leaves open translation to human RNA virus therapies.

Structured PICO

Population

Cells infected with mutant positive-strand RNA virus

Intervention

Introduction of catalytically inactive polymerases or polymerases with amino terminus mutations

Comparator

Active polymerases

Outcome

RNA template elongation and functional oligomer formation

Targeting the multimeric arrays of RNA-dependent RNA polymerase, rather than just the active sites, may provide a novel and more effective antiviral strategy.

Cite This Study

Spagnolo et al. (2010) studied this question.

synapsesocial.com/papers/6a850ed939166d68e0e592dc https://doi.org/10.1261/rna.1955410

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Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider