Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 25, 2007Journal of VirologyOpen Access

Crystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA Polymerase

View Full Paper
Ask AI
Bookmark
Share

Population

Poliovirus 3CD protein and G64S fidelity mutant of 3D(pol)

Design

Preclinical

Authors

LMLaura L. MarcotteAssumption CollegeAWAmanda B. WassCleveland ClinicDGDavid W. GoharaClinical Research Consultants (United States)

Discussion

Loading...

Member takes

Overview

Preclinical structures of poliovirus 3CD offer no immediate clinical guidance; leaves open functional validation for antiviral targeting.

Structured PICO

P
Population
Poliovirus 3CD protein and G64S fidelity mutant of 3D(pol)
I
Intervention
Crystal structure determination
O
Outcome
Crystal structures of 3CD and G64S fidelity mutant of 3D(pol)

The crystal structure of poliovirus 3CD provides insights into its role in viral replication and the control of VPg uridylylation.

Cite This Study

Marcotte et al. (2007) studied this question.

synapsesocial.com/papers/6a6f694a26a7f98052dc13ffhttps://doi.org/10.1128/jvi.02306-06
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of the RNA Binding and Protein Processing Activities of Poliovirus Polypeptide 3CD by the Viral RNA Polymerase Domain1999 · 64 citations
  2. 2Mutation of lysine residues in the nucleotide binding segments of the poliovirus RNA-dependent RNA polymerase1996 · 20 citations
  3. 3Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Purification and Enzymatic Analysis of the RNA-Dependent RNA Polymerase 3D pol2001 · 28 citations
  4. 4Similar Structural Basis for Membrane Localization and Protein Priming by an RNA-dependent RNA Polymerase2002 · 76 citations
  5. 5Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Identification of a cis -Replicating Element in the Coding Sequence of 2A pro2001 · 104 citations