Key result
Engineering flexible RNA contacts allowed the determination of nine new high-resolution structures of poliovirus, coxsackievirus, and rhinovirus polymerase elongation complexes.
Population
Viral RNA-dependent RNA polymerases (poliovirus, coxsackievirus, and rhinovirus elongation complexes)
Design
Preclinical
Authors
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New structures of picornavirus polymerases now accessible; leaves open any role in guiding antivirals for enteroviral myocarditis.
Engineering flexible RNA contacts to promote crystal lattice formation is a versatile platform for solving structures of viral RdRP elongation complexes and catalytic cycle intermediates.
Gong et al. (2013) studied this question. Engineering flexible RNA contacts allowed the determination of nine new high-resolution structures of poliovirus, coxsackievirus, and rhinovirus polymerase elongation complexes.
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